Spermidine can counteract the general age-related cycle by having a broad effect on cellular health and may have specific effects on various organ systems involved in, for example, cardiovascular function, immune responses to cancer or neurodegeneration, thereby reducing the incidence of age-related diseases.
Recent epidemiological findings suggest that an increased intake of spermidine in food also reduces overall as well as cardiovascular and cancer-related fatalities in humans. Scientists T. Eisenberg and F. Madeo discovered that spermidine helps human immune cells survive longer.
It is a polyamine. Polyamines are mainly found in in large quantities inside the nucleus of human cells. Spermidine and spermine are responsible for the health of each cell (cellular health). Polyamines are sometimes also referred to as plant hormones because they play a role in the aging of a plant.
Polyamines such as spermidine and spermine are widely found in our brains. We can produce them ourselves but it is advisable to ingest sufficient quantities of them. They help us to grow old healthily. There have been 2 epidemiological studies that have proven scientifically that spermidine helps people to stay healthier as they age for a longer period of time (12,14,15).
Please note: Spermidine is a polyamine derived from putrescine. Spermidine is a precursor of spermine.
“Given that polyamines can interact with many molecules, it is not surprising that they affect aging via several mechanisms. Many of these mechanisms discovered so far have already been linked with aging and by acting on all of these mechanisms, polyamines may be strong regulators of aging.” – University of St Andrews, North Haugh, S. Karger AG, Basel
What are good sources of spermidine?
Spermidine is water-soluble, rinsing in water drastically reduces spermidine in food.
- In general:
- fruit is low in spermidine,, the winner is mango with 3 mg/100g
- meat and fish are low in spermidine, the winner is minced beef with 4mg/100g
- nuts and dried fruit are low in spermidine: the winner are hazelnuts with 2mg/100g
- vegetables are low in spermidine, the winner is corn with 3mg/100g
- 33.4 mg/100g Amanprana wheat germ (35% more than standard wheat germ)
- 24.3 mg/100g Wheat germ
- 19 mg/100g cheddar cheese
- 6 – 14 mg/100g peas
- 19 mg/100g red beans
- 2- 10 mg/100g broccoli and cauliflower
- 9 mg/100g Champignons de Paris mushrooms
- 3 mg/100g mango
- 3 mg/100g chickpeas
- 3 mg/100g corn
- 2 mg/100g celery and melon
- 2 mg/100g wholegrain bread
source : https://spermidin-kapseln.de
“Spermidine obtained via food increases lifespan and significantly reduces age-related oxidative protein damage, indicating that it can act as a universal anti-aging drug.” -Spermidine: A Novel Autophagy Inducer and Longevity Elixir. Scientists: Frank Madeo 1 , Tobias Eisenberg, Sabrina Büttner, Christoph Ruckenstuhl.
What does spermidine do? It achieves homeostasis!
- Spermidine can improve the permeability of the blood-brain barrier.
- Spermidine is involved in the aging process of organs (in plants) (20)
- Spermidine is involved in the regulation of programmed cell death (21) (cancer)
- Spermidine and spermine can prolong our lives and improve our health across various levels (2,3)
- Spermidine can suppress cardiovascular age-related degradation by 10%. Which can mean an 8 extra years of life for people (3)
- Spermidine delays the development of cancer in mice, even after administration of carcinogenic substances (4,5).
- Spermidine slows down the breakdown of nerve structures and nerve functions. That is important when it comes to Parkinson’s, Alzheimer’s, Huntington’s and ALS (6,7,8).1555864266
- The spermidine level in blood predicts the likelihood of us becoming ill and dying. The more spermidine, the better equipped against age-related illnesses and death due to age-related illnesses. Two scientific studies on humans have proven this (15). Consequently, Spermidine could add more healthy years to your life.
- Spermidine boosts our health by inhibiting the EP300 gene. Just like an aspirin is supposed to do but without the side effects. Whereby Spermidine also has an anti-clotting (anticoagulant effect). (17,18)
- Spermidine stimulates cells to remove their waste more quickly, thereby enabling people to live longer. (22)
- Spermidine prolongs the life of our immune cells. As a result, their tests found that mice suffered less cell damage caused by aging. (According to the Austrian scientists Tobias Eisenberg and Frank Madeo.
Nothing else helps as well as Spermidine does to dispose of waste in our body (autophagy inductor) and it also serves as an aid in achieving homeostasis. Ally of intermittent fasting.
What is autophagy?
Autophagy is simply our own natural, self-regulating mechanism whereby our cells remove unnecessary and non-functional substances.
It is important when it comes to inflammation, infections, cell repair, stress, physical exertion, osteoarthritis and cell death of cancer cells. Autophagy in Greek means ‘to consume oneself.’
Belgian scientist Christian de Duve discovered that the human body recycles its own waste from its cells in a clever way. The body turns it back into building materials. Autophagy is essential for achieving homeostasis.
What is homeostasis?
Homeostatis is a self-regulating process whereby the body tries to balance its internal environment. Homeostatis regulates conditions such as oxygen levels, blood pressure, sugar levels, temperature and our acidity levels. (Claude Bernard en Walter Bradsford Cannon in the Wisdom of the Body (1932) Both mechanisms are important in order to grow very old with excellent health.
Intermittent fasting, also known as intermittent energy restriction. Intermittent fasting gives your body and mind time to recuperate, to remove waste products, to recover.
Sources mentioning spermidine:
Aging (Albany NY). 2018 Aug; 10(8): 2209–2211. Published online 2018 Aug 6. doi: 10.18632/aging.101517 PMCID: PMC6128428, PMID: 30082504, Spermidine delays aging in humans
Frank Madeo,1,2 Didac Carmona-Gutierrez,1,2 Oliver Kepp,3,7 and Guido Kroemer 3-,9
- Madeo F, et al. Science. 2018; 359:359. 10.1126/science.aan2788 [PubMed] [CrossRef] [Google Scholar]
- Eisenberg T, et al. Apoptosis. 2007; 12:1011–23. 10.1007/s10495-007-0758-0 [PubMed] [CrossRef] [Google Scholar]
- Eisenberg T, et al. Nat Med. 2016; 22:1428–38. 10.1038/nm.4222 [PMC free article] [PubMed] [CrossRef] [Google Scholar]
- Pietrocola F, et al. Cancer Cell. 2016; 30:147–60. 10.1016/j.ccell.2016.05.016 [PMC free article] [PubMed] [CrossRef] [Google Scholar]
- Yue F, et al. Cancer Res. 2017; 77:2938–51. 10.1158/0008-5472.CAN-16-3462 [PMC free article] [PubMed] [CrossRef] [Google Scholar]
- Büttner S, et al. Cell Cycle. 2014; 13:3903–08. 10.4161/15384101.2014.973309 [PMC free article] [PubMed] [CrossRef] [Google Scholar]
- Noro T, et al. Cell Death Dis. 2015; 6:e1720. 10.1038/cddis.2015.93 [PMC free article] [PubMed] [CrossRef] [Google Scholar]
- Noro T, et al. Invest Ophthalmol Vis Sci. 2015; 56:5012–19. 10.1167/iovs.15-17142 [PubMed] [CrossRef] [Google Scholar]
- Pietrocola F, et al. Cell Death Differ. 2015; 22:509–16. 10.1038/cdd.2014.215 [PMC free article] [PubMed] [CrossRef] [Google Scholar]
- Mariño G, et al. Mol Cell. 2014; 53:710–25. 10.1016/j.molcel.2014.01.016 [PubMed] [CrossRef] [Google Scholar]
- Eisenberg T, et al. Nat Cell Biol. 2009; 11:1305–14. 10.1038/ncb1975 [PubMed] [CrossRef] [Google Scholar]
- Rubinsztein DC, et al. Cell. 2016; 166:802–21. 10.1016/j.cell.2016.07.031 [PubMed] [CrossRef] [Google Scholar]
- Madeo F, et al. J Clin Invest. 2015; 125:85–93. 10.1172/JCI73946 [PMC free article] [PubMed] [CrossRef] [Google Scholar]
- Kiechl S, et al. Am J Clin Nutr. 2018. 10.1093/ajcn/nqy102 [PubMed] [CrossRef] [Google Scholar]
- Madeo F, et al. Nat Rev Drug Discov. 2014; 13:727–40. 10.1038/nrd4391 [PubMed] [CrossRef] [Google Scholar]
- Pietrocola F, et al. Cell Reports. 2018; 22:2395–407. 10.1016/j.celrep.2018.02.024 [PMC free article] [PubMed] [CrossRef] [Google Scholar]
- Pietrocola F, et al. Autophagy. 20181–2. 10.1080/15548627.2018.1454810 [PMC free article] [PubMed] [CrossRef] Google Scholar:
- Zhang L, Lee HK, Pruess TH, White HS, Bulaj G (March 2009). “Synthesis and applications of polyamine amino acid residues: improving the bioactivity of an analgesic neuropeptide, neurotensin”. J. Med. Chem. 52 (6): 1514–7. doi:10.1021/jm801481y. PMC 2694617. PMID 19236044.
- (20) : Pandey S, Ranade SA, Nagar PK, Kumar N (September 2000). “Role of polyamines and ethylene as modulators of plant senescence”. J. Biosci. 25 (3): 291–9. doi:10.1007/BF02703938. PMID 11022232.
- (21) : Moschou, PN; Roubelakis-Angelakis, KA (Nov 11, 2013). “Polyamines and programmed cell death”. Journal of Experimental Botany. 65 (5): 1285–1296. doi:10.1093/jxb/ert373. PMID 24218329
- (22) : Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin in humans? Frank Madeo, Maria A. Bauer, Didac Carmona-Gutierrez & Guido Kroemer , Pages 165-168 | Received 16 Aug 2018, Accepted 24 Sep 2018, Published online: 11 Oct 2018